Product Name | Kininogen 1 Rabbit pAb |
Cat Number | HR1APEA367 |
Source | Rabbit |
Applications | WB, IHC |
Species Reactivity | Human,Mouse,Rat |
Recommended Dilutions | WB 1:1500-1,000 IHC 1:100-200 |
Specificity | Human |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
Clonality | Polyclonal |
Isotope | IgG |
Concentration | 1mg/ml |
Observed Band | 45-120kDa |
Gene ID | 3827 |
Alternative Name | BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1 |
Background | Kininogens are inhibitors of thiol proteases; HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clottingUCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all posses a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL1 is abundantly expressed in neuronal tissues and testes. |
Type | polyclonal |