| Product Name | CK16 Mouse mAb |
| Cat Number | HR1AM2167 |
| Source | Mouse |
| Applications | IHC |
| Species Reactivity | Human,Rat,Mouse |
| Recommended Dilutions | IHC 1:200 |
| Specificity | Human |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotope | IgG1 |
| Concentration | 1mg/ml |
| Observed Band | 51kDa |
| Gene ID | 3868 |
| Alternative Name | Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK |
| Background | Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. |
| Type | monoclonal |