Claudin-2 (8H11) Mouse mAb

Claudin-2 (8H11) Mouse mAb

Cat No.:HR1AM2514
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  Product info

Alternative Name: N/A

Antibodies Type: monoclonal

Product Details

Product Name Claudin-2 (8H11) Mouse mAb
Cat NumberHR1AM2514
ApplicationsWB, IHC
Species Reactivity Human,Rat,Mouse
Recommended Dilutions WB 1:1,000-2,000   IHC:1;100-1:200
Specificity Human
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality Monoclonal
Isotope IgG1
Concentration 1mg/ml
Observed Band 25kDa
Gene ID 9075
Alternative Name N/A
Background The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .
Type monoclonal

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