| Product Name | Dnmt3b Polyclonal Antibody |
| Cat Number | HR1AP3300 |
| Source | Rabbit |
| Applications | WB,IHC-p,IF,ELISA |
| Species Reactivity | Human,Chicken(testedbyourcustomer? |
| Storage | -20°C/1 year |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Observed Band | 96 |
| Gene ID | DNMT3B |
| Alternative Name | DNMT3B; DNA (cytosine-5)-methyltransferase 3B; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB |
| Background | DNA methyltransferase 3 beta(DNMT3B) Homo sapiens CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011], |
| Type | polyclonal |