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New therapeutic target for cancer: Inflammation

Due to the progress of research in the field of cancer, Inflammation is now considered as hallmark of cancer. Research has already proved that only cell proliferation does not cause cancer, it’s the sustained proliferation of cell in an environment consisting of inflammatory cells, activated stroma, growth factors, and agents promoting DNA-damage, definitely promotes the formation of neoplasm. Chronic inflammation shapes the tumor microenvironment, affecting cell plasticity through epithelial–mesenchymal transition, dedifferentiation, polarization of immune cells, ROS, cytokines, miRNAs, epigenetic mechanisms, and complex regulatory cascades in tumor and stromal cells. Not all the inflammatory diseases are prone to cancer risk.

Various molecular pathways and stroma cells are targeted ranging from hypoxia, epigenetic factors, neoangiogenesis, and cytokines over tumor and tumor associated cells. There has been development and clinical approval of CTLA-4 or PD-1/PD-L1 targeted antibody-based immunotherapy.

The field of cancer-related inflammation has enormously expanded with the discovery of multiple cellular and molecular mechanisms which illustrates the complex interaction of immune cells, stromal cells, vascular cells, and tumor cells and the impact of multiple external factors. Majority of immune cells have been shown to be multimodal combinatorial approaches that targets both tumor cell extrinsic and intrinsic pathways will most likely represent the future of modern cancer therapy.

Some recent researches have proved that disrupting the NO production can reduce inflammation around the tumors which causes tumor-targeting immune cells to penetrate the tumors leading to cytoxicity of cancer cells. Further it has been reported that consumption of anti-inflammatory drugs can reduce the risk of cancer. Also, non-steroidal anti-inflammatory drugs (NSAID) and Cox-2 inhibitors specifically aids in the cancer prevention.

Bioelsa is proud to offer an extensive range of Products to support the research in the field cancer and inflammation.

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