Claudin-2 (8H11) Mouse mAb

Claudin-2 (8H11) Mouse mAb

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  Product info

Catalog No: EM1403

For research use only.

Source: Mouse

Applications: WB IHC

Species reactivity: Human Rat Mouse

Recommended dilutions: WesternBlot:1/1000-2000 Immunohistochemistry:1/100-1/200
NOTE: Optimal dilutions should be determined by the end user.

Immunogen: Synthetic Peptide

Species: Human

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

S.No Query
Isotype IgG1
Clonality Monoclonal
Concentration 1 mg/ml
Observed band 25kDa
GeneID(Human) 9075
Human Swiss-Prot No. P57739
Cellular Localization Cell junctiontight junctionCell Membrane
Background The claudin family is composed of 23 integral membrane proteins and their expression which varies among tissue types may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney where it regulates transepithelial ion (e.g. Na+ Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines

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