Gene ID | N/A |
Accession | NM_001007798 |
Alternative Name | AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK |
Species | Rat |
Source | Insect cells |
Description | BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors .Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments . |
Accession | NM_001007798 |
Functions | The specific activity of BTK was determined to be 66 nmol /min/mg as per activity assay protocol. |
Formulation | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 105 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |