| Gene ID |
116562 |
| Accession | P17108 |
| Alternative Name | T-cell growth factor |
| Species | Rat |
| Source | E. coli |
| Description | Rat IL2, also known as T-cell growth factor, is a secreted immunoregulatory cytokine produced by T-cells due to antigenic or mitogenic stimulation. IL2 binds to the IL2 receptor, which is found in T and B cells and natural killer cells, and is composed of three distinct components: the cytokine specific ?-chain, and the ?? and ?c-subunits. Its receptor complex IL2 induces the proliferation of T cells, generation of cytotoxic T lymphocytes (CTLs), proliferation and synthesis of immunoglobulin by B cells, and the survival of natural killer cells. Its heterotrimeric receptor complex is also shared by Interleukin 4 (IL4) and Interleukin 7 (IL7) by its gamma chain, and receptor signalling is essential for its expression and differentiation of regulatory T cells in the immune response. |
| Accession | P17108 |
| Functions | The ED50 was 0.04-0.2 ng/mL as determined by a cell proliferation assay |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in ammonium acetate and glycerol (with BSA as a carrier protein) |
| Solubility | N/A |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15.6 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles. |
