| Gene ID | |
| Accession | ACI28624.1 |
| Source | Baculovirus-Insect Cells |
| Description | This recombinant protein is a class I viral fusion protein that mediates viral attachment, host cell entry and membrane fusion and serves as the sole surface-exposed viral antigen critical for infectivity. GP is synthesized as a precursor and cleaved by host proteases, including furin, to generate the disulfide-linked subunits GP1 and GP2; GP1 constitutes the extracellular, receptor-binding component of the trimeric spike and contains the receptor-binding domain as well as a heavily glycosylated mucin-like region implicated in immune evasion, while GP2 anchors the complex in the viral membrane and mediates membrane fusion during endosomal entry. The GP gene also produces a secreted glycoprotein (sGP) via RNA editing, which shares the N-terminal sequence with GP1 but diverges at the C-terminus and is proposed to function as an immune decoy. Due to its essential role in viral entry and surface accessibility, GP1 is widely utilized in vaccine design, neutralizing antibody development and antiviral research. |
| Accession | ACI28624.1 |
| Appearance | Lyophilized powder |
| Molecular Weight | 53.5 kDa |
| Purity | >95% (SDS-PAGE) |
| Storage Condition | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |