| Gene ID | 5919 |
| Accession | Q99969 |
| Alternative Name | RAR-responsive protein TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RARRES2 |
| Species | Human |
| Source | E. coli |
| Description | Human Chemerin, also known as Tazarotene induced Gene 2 (TIG2), is an adipokine that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1. Its other ligands include G protein-coupled receptor 1 and chemokine receptor-like 2. Chemerin is expressed in various tissues where its biologically active form is generated by proteolytic removal of C-terminal residues by circulating proteases. In human, the soluble protoform gets processed into a monomeric, heparin binding bioactive molecule that can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. |
| Accession | Q99969 |
| Functions | Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human ChemR23. The ED(50) for this effect is typically 4 - 20 ng/mL. |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS |
| Solubility | Reconstitute at 0.1 mg/mL in sterile PBS |
| Appearance | Lyophilized Powder |
| Molecular Weight | 16 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |