Recombinant Human CHK2 (N-GST tag)


Recombinant Human CHK2 (N-GST tag)

Cat No.:HR2R1272
Product available

  Product info

Quantity: 10 μg

Gene Symbol: CHK2
Product Details

Gene ID N/A
Accession NM_007194
Alternative NameRP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53
SpeciesHuman
SourceInsect cells
Description CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner . Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization .
Accession NM_007194
Functions The specific activity of CHK2 was determined to be 808 nmol /min/mg as per activity assay protocol.
Formulation50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Solubility N/A
Appearance Liquid
Molecular Weight88
Purity70% - 90%
Shipping ConditionDry Ice
Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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