| Gene ID |
1490 |
| Accession | P29279 |
| Alternative Name | CTGF, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, HCS24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8<br/>Recombinant Human Connective Tissue Growth Factor (CTGF) |
| Species | Human |
| Source | E. coli |
| Description | Secreted by vascular endothelial cells, CTGF is a regulatory protein that has been shown to stimulate the growth of chondrocytes, promote angiogenesis and mediate cell adhesion of fibroblasts and endothelial cells. The binding of CTGF to heparin induces cell migration and adhesion. Mature Human CTGF is a 38.0 kDa secreted protein that is comprised of four distinct structural domains (a) IGFBP N-terminal domain (b) VWFC domain (c) TSP type-I domain and (d) C-terminal CTCK domain. Recombinant Human CTGF is an 11.3 kDa protein monomeric protein that maps to the CTCK domain. |
| Accession | P29279 |
| Functions | Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 μg/ml. |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS |
| Solubility | Reconstitute at 100 μg/mL in sterile PBS |
| Appearance | Lyophilized Powder |
| Molecular Weight | 11.3 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles. |
