| Gene ID | 3604 |
| Accession | Q07011 |
| Alternative Name | Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CD_antigen=CD137, CD137, ILA<br/>Recombinant Human 4-1BB (TNFRSF9) |
| Species | Human |
| Source | CHO cells |
| Description | 4-1BB Receptor (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated natural killer cells. The binding of 4-1BB to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a costimulatory signal to resting T cells leading to high level IL-2 production independently of CD28 signaling. |
| Accession | Q07011 |
| Functions | The activity was tested by the ability of immobilized recombinant mouse 4-1BBL to bind human 4-1BB with a linear range of 10-500 ng/mL. |
| Formulation | Recombinant Human CD137 is lyophilized from 0.2 ?m filtered PBS solution, pH7.2. |
| Solubility | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Appearance | Lyophilized Powder |
| Molecular Weight | 65 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | Recombinant Human CD137 can be stored in working aliquots at 2? - 8?C for one month, or at -20?C to -70?C for twelve months. Avoid repeated freeze/thaw cycles. |