Recombinant Human DCAMKL2 (N-GST tag)


Recombinant Human DCAMKL2 (N-GST tag)

Cat No.:HR2R1322
Product available

  Product info

Quantity: 10 μg

Gene Symbol: DCAMKL2
Product Details

Gene ID N/A
Accession NM_001040261
Alternative NameDCLK2; DCK2; DCDC3; DCDC3B; DKFZp761I032; MGC45428
SpeciesHuman
SourceInsect cells
Description DCAMKL2 (also known as doublecortin-like kinase 2 or DCLK2) is a close homologue of doublecortin or DCX which is associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. DCX; DCLK2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. DCX and DCLK2 are co-expressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone .?
Accession NM_001040261
Functions The specific activity of DCAMKL2 was determined to be 94 nmol /min/mg as per activity assay protocol
Formulation50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Solubility N/A
Appearance Liquid
Molecular Weight105
Purity70% - 90%
Shipping ConditionDry Ice
Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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