Recombinant Human DMPK (N-GST tag)


Recombinant Human DMPK (N-GST tag)

Cat No.:HR2R1328
Product available

  Product info

Quantity: 10 μg

Gene Symbol: DMPK
Product Details

Gene ID N/A
Accession NM_004409
Alternative NameDM, DM1, DMK, MDPK, DM1PK, MT-PK
SpeciesHuman
SourceInsect cells
Description DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein . Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3' untranslated region of DMPK .
Accession NM_004409
Functions The specific activity of DMPK was determined to be 4.5 nmol/min/mg as per activity assay protoco
Formulation50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Solubility N/A
Appearance Liquid
Molecular Weight105
Purity70% - 90%
Shipping ConditionDry Ice
Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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