| Gene ID | N/A |
| Accession | NM_004836 |
| Alternative Name | PERK, PEK, WRS, HRI, DKFZp781H1925 |
| Species | Human |
| Source | Insect cells |
| Description | EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation and a rapid reduction of translational initiation and repression of global protein synthesis. EIF2AK3 is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins . EIF2AK3 plays a major role in the ability of cells to adapt to ER stress and is also involved in an integrated adaptive response to hypoxic stress in HeLa cells . EIF2AK3 functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia. |
| Accession | NM_004836 |
| Functions | The specific activity of EIF2K3 was determined to be 18 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 115 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |