Recombinant Human ALK1 (N-GST tag)

Recombinant Human ALK1 (N-GST tag)

Cat No.:HR2R1135
Product available

  Product info

Quantity: 10 μg

Gene Symbol: ALK1
Product Details

Gene ID N/A
Accession NM_000020
Alternative NameACVRL1, ACVRLK1, ALK1, HHT, HHT2, ORW2, SKR3, ALK1, TSR-I
SourceInsect cells
Description ?ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGF? superfamily . ALK1 functions as a TGF? type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGF? signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported .
Accession NM_000020
Functions The specific activity of ALK1 was determined to be 22 nmol /min/mg as per activity assay protocol.
Formulation50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Solubility N/A
Appearance Liquid
Molecular Weight64
Purity70% - 90%
Shipping ConditionDry Ice
Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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