Gene ID | N/A |
Accession | NM_153831 |
Alternative Name | PTK2, FADK, FAK1, pp125FAK |
Species | Human |
Source | Insect cells |
Description | FAK (Focal Adhesion Kinase ) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation . Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness . Elevated FAK expression in anaplastic astrocytoma and glioblastoma tumor biopsy samples has been demonstrated.? |
Accession | NM_153831 |
Functions | The specific activity of FAK was determined to be 230 nmol /min/mg as per activity assay protocol. |
Formulation | 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 35 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |