| Gene ID |
26291 |
| Accession | Q9NSA1 |
| Alternative Name | FGF-21<br/>Recombinant Human Fibroblast Growth Factor 21 (FGF21) |
| Species | Human |
| Source | E. coli |
| Description | FGF-21 is a secreted growth factor of the FGF family, classified as an FGF-19 subfamily member. Proteins of the FGF family are known to play a central role with respect to both prenatal and postnatal growth and development, and regeneration of a variety of tissues by promoting cellular proliferation and differentiation. In the presence of beta Klotho (protein cofactor), FGF-21 signals via the FGFR receptors to stimulate insulin independent glucose uptake by adipocytes. |
| Accession | Q9NSA1 |
| Functions | The bioactivity was determined in a NIH/3T3 cell proliferation assay with an ED50 <1ng/ml. |
| Formulation | Lyophilized from 0.2 ?m filtered solution in Tris and NaCl (pH 8.0) |
| Solubility | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19.7 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2?- 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
