| Gene ID | 6376 |
| Accession | P78423 |
| Alternative Name | C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1 |
| Species | Human |
| Source | E. coli |
| Description | Fractalkine is a type I membrane protein that signals through the CX3CR1 receptor. The extracellular domain of Fractalkine is released by protease cleavage ? producing soluble Fractalkine. Fractalkine has been found in many tissues and shown to be up-regulated in endothelial cells and microglia in response to inflammatory signals. Fractalkine is also involved in leukocyte adhesion as well as attracting monocytes, microglia cells and NK cells. |
| Accession | P78423 |
| Functions | Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CX3CR1. The ED(50) for this effect is typically 20?100 ng/mL |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS with BSA as a carrier protein |
| Solubility | Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin |
| Appearance | Lyophilized Powder |
| Molecular Weight | 8.9 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |