| Gene ID | N/A |
| Accession | NM_004579 |
| Alternative Name | MAP4K2, BL44, RAB8IP |
| Species | Human |
| Source | Insect cells |
| Description | μgCK is a serine/threonine protein kinase that is activated by TNFa and interacts with the TNF receptor-associated factor 2 (TRAF2). GCK is upstream of MAP kinases and particularly activates the SAPK pathway . Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to GCK can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/GCK may modulate secretion in response to stress stimuli . |
| Accession | NM_004579 |
| Functions | The specific activity of GCK was determined to be 290nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 125 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |