Gene ID | N/A |
Accession | NM_003618 |
Alternative Name | MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1 |
Species | Human |
Source | Insect cells |
Description | GLK is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. GLK is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-? and can lead to the activation of the JNK signaling pathway. GLK can directly activate PKC-? during TCR signaling and people with systemic lupus erythematosus show considerable enhanced GLK expression and activation of PKC-? and the kinase IKK in T cells . GLK can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM . |
Accession | NM_003618 |
Functions | The specific activity of GLKwas determined to be 92nmol/min/mg as per activity assay protocol. |
Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 70 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |