Gene ID | N/A |
Accession | NM_005160 |
Alternative Name | ADRBK2; BARK2 |
Species | Human |
Source | Insect cells |
Description | GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function . GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue . Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have been associated with bipolar disorder. |
Accession | NM_005160 |
Functions | The specific activity of GRK3 was determined to be 6 nmol /min/mg as per activity assay protocol. |
Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 84 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |