Gene ID | N/A |
Accession | NM_005734 |
Alternative Name | PKY, YAK1, DYRK6, FIST3 |
Species | Human |
Source | Insect cells |
Description | HIPK3 (homeodomain interacting protein kinase 3) is a member of the HIPK family and is involved in apoptosis . JNK regulates the expression of HIPK3 in prostate cancer cells and this contributes to increased resistance to Fas receptor-mediated apoptosis by reducing the interaction between FADD and caspase-8 . HIPK3 has been reported to phosphorylate FADD and is implicated in multidrug resistance in a number of tumors. HIPK3 increases transcription factor SF-1 activity leading to increased steroidogenic gene expression in response to cAMP signaling.? |
Accession | NM_005734 |
Functions | The specific activity of HIPK3 was determined to be 48 nmol/min/mg as per activity assay protocol |
Formulation | 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 49 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |