Gene ID | N/A |
Accession | BC092514 |
Alternative Name | CHUK, IKK1, IKBKA, TCF16, NFKBIKA, IKK-alpha |
Species | Human |
Source | Insect cells |
Description | IKKa is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex . IKKa is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure . IKKa is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFNa production. IKKa is also involved in the epidermis where it antagonizes mitogenic and angiogenic signals and represses tumor progression and metastases. |
Accession | BC092514 |
Functions | The specific activity of IKKa was determined to be 2.5 nmol /min/mg as per activity assay protocol. |
Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 114 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |