Recombinant Human IKK beta (N-GST tag)


Recombinant Human IKK beta (N-GST tag)

Cat No.:HR2R1532
Product available

  Product info

Quantity: 10 μg

Gene Symbol: IKK beta
Product Details

Gene ID N/A
Accession NM_001556
Alternative NameIKK2, IKBKB, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801
SpeciesHuman
SourceInsect cells
Description IKK? is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKK? is stimulated by TNF and IL1 and IKK? forms a heterodimer that interacts with NIK . Overexpression of catalytically inactive IKK? blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKK? activity in vitro and in vivo by binding to IKK? to reduce ATP binding .
Accession NM_001556
Functions The specific activity of IKK? was determined to be 58 nmol /min/mg as per activity assay protocol.
Formulation50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Solubility N/A
Appearance Liquid
Molecular Weight105
Purity70% - 90%
Shipping ConditionDry Ice
Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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