| Gene ID | N/A |
| Accession | NM_001556 |
| Alternative Name | IKK2, IKBKB, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801 |
| Species | Human |
| Source | Insect cells |
| Description | IKK? is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKK? is stimulated by TNF and IL1 and IKK? forms a heterodimer that interacts with NIK . Overexpression of catalytically inactive IKK? blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKK? activity in vitro and in vivo by binding to IKK? to reduce ATP binding . |
| Accession | NM_001556 |
| Functions | The specific activity of IKK? was determined to be 58 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 105 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |