| Gene ID |
3558 |
| Accession | P60568 |
| Alternative Name | IL-2, T-cell growth factor, TCGF, INN=Aldesleukin<br/>Recombinant Human Interleukin-2 (IL2) |
| Species | Human |
| Source | CHO cells |
| Description | IL-2 is produced mainly by T cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T cell proliferation. Th1 and Th2 effector T cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas- mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses. |
| Accession | P60568 |
| Functions | The ED(50) was determined by the dose dependent proliferation of murine CTLL-2 cells and was found to be less than 0.1 ng/mL, corresponding to a specific activity of > 2.0 x 10^7 units/mg. |
| Formulation | Recombinant Interleukin-2 was lyophilized from a 0.2 ?m filtered concentrated (1.0 mg/mL) solution in PBS, pH 7.2. |
| Solubility | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
