| Gene ID |
282616 |
| Accession | Q8IZJ0 |
| Alternative Name | Zcyto20, Interleukin-28A, Interferon lambda-2 |
| Species | Human |
| Source | E. coli |
| Description | Interferon lambda-2, also known as Interleukin 28A, is an antiviral cytokine with immunomodulatory activity and is distantly related to the IL-10 family and type I interferons. IL28A along with IL29 and IL28B, are three closely related cytokines that form a cytokine gene cluster that use a distinct receptor system which induces antiviral defence signals. IL28A interacts with a heterodimeric class II cytokine receptor ligand and leads to the activation of the JAK/STAT signalling pathway, which ultimately leads to IFN-stimulated gene (ISG) and MHC class I antigen expression. It also plays a key role in antiviral defence in Toll-like receptors (TLR) and intestinal epithelia. |
| Accession | Q8IZJ0 |
| Functions | The ED50 is 10.0-50.0 ng/mL as determined by an anti-viral assay (using human hepatocellular carcinoma cells infected with EMC virus) |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS |
| Solubility | Reconstitute in sterile PBS at 100μg/mL (containing at least 0.1% human or bovine serum albumin) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19.5 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles. |
