| Gene ID | 27178 |
| Accession | Q9NZH6 |
| Alternative Name | IL-37, IL-23, FIL1 zeta, IL-1X, Interleukin-1 family member 7, IL-1F7, Interleukin-1 homolog 4, IL-1H, IL-1H4, Interleukin-1 zeta, IL-1 zeta, Interleukin-1-related protein, IL-1RP1<br/>Recombinant Human Interleukin-37/Interleukin-23 (IL37/IL23) |
| Species | Human |
| Source | E. coli |
| Description | Member of the IL-1 family, IL-37 functions to curb excessive inflammation. In partnership with SMAD3, IL-37 suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Out of the five isoforms for IL-37 (a-e), this product represents isoform B that is expressed in testis, colon, placenta, lung and lymph node similar to isoform A and C but is the only one found in kidneys. |
| Accession | Q9NZH6 |
| Functions | N.A. |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS and DTT |
| Solubility | Reconstitute at 100 μg/mL in sterile PBS |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19.5 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |