| Gene ID | 9048 |
| Accession | Q5T4W7 |
| Alternative Name | Enovin, Neublastin |
| Species | Human |
| Source | E. coli |
| Description | Artemin is a disulfide-linked member of the glial cell line-derived homodimeric neurotrophic factor (GDNF) family which all signal via a multicomponent receptor system composing of a high-affinity binding component (GFR?1-4) and a common signalling receptor tyrosine kinase (RET). Artemin prefers the receptor GFR?3-RET, but will use the others as an alternative. Artemin promotes the survival and growth of peripheral and central neurons, including dopaminergic neurons in the mid-brain; and plays an important role in the development of sensory and sympathetic neurons. |
| Accession | Q5T4W7 |
| Functions | The ED50 as determined by its binding ability in a functional ELISA (using SH-SY5Y human neuroblastoma cells), is 4-16 ng/mL |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in HCl (with BSA as a carrier protein) |
| Solubility | Reconstitute in sterile 4mM HCl at 100 μg/mL (containing at least 0.1% human or bovine serum albumin) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 12.2 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | < 1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |