| Gene ID |
3578 |
| Accession | P15248 |
| Alternative Name | Cytokine P40, T-cell growth factor P40 |
| Species | Human |
| Source | E. coli |
| Description | Interleukin 9 (IL9) is an immunoregulatory cytokine belonging to the IL-7/IL-9 cytokine family. Commonly produced by TH17 cells, IL9 acts as a hematopoietic cell regulator by preventing apoptosis and stimulates cell proliferation of T lymphocytes, erythroid cells, and mast cells. It binds to the IL9 receptor (IL9R) to activate different signal transducer and activator (STAT) proteins. It also supports IL2 and IL4 independent growth of helper T-cells and affects TH17 and Tregs through STAT3 and STAT5 signalling activation. Furthermore, IL9 has been found to be a candidate gene for asthma as its presence determines the pathogenesis of bronchial hyper-responsiveness. Although human and mouse IL9 share a 56% amino acid identity, human IL9 is not active on mouse cells and can be found to inhibit melanoma growth in mice. |
| Accession | P15248 |
| Functions | The ED50 is 0.1-0.6 ng/mL as determined by a cell proliferation assay |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS (with BSA as a carrier protein) |
| Solubility | Reconstitute in sterile PBS at 100μg/mL (containing at least 0.1% human or bovine serum albumin) |
| Appearance | Lyophilized Powder |
| Molecular Weight | N/A |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles. |
