| Gene ID |
7873 |
| Accession | P55145 |
| Alternative Name | Arginine-rich protein, Protein ARMET, ARP<br/>Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) |
| Species | Human |
| Source | E. coli |
| Description | MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF. |
| Accession | P55145 |
| Functions | The ED50 was found to be <0.5ng/ml using dose dependent proliferation of human pancreatic cells. |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS |
| Solubility | Reconstitute at 200 μg/mL in PBS |
| Appearance | Lyophilized Powder |
| Molecular Weight | 18.4 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles. |
