| Gene ID | N/A |
| Accession | NM_001039469 |
| Alternative Name | EMK1, PAR-1, MGC99619 |
| Species | Human |
| Source | Insect cells |
| Description | MARK2 or microtubule affinity-regulating kinase 2 is a member of the Par-1 family of serine/threonine protein kinases. MARK2 is an important regulator of cell polarity in epithelial and neuronal cells and controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins . MARK2 is a key target of H. pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation, and carcinogenesis . MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. MARK2 function in the establishment of T cell polarity following engagement to an APC. |
| Accession | NM_001039469 |
| Functions | The specific activity of MARK2 was determined to be795 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 114 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |