Gene ID | N/A |
Accession | NM_006609 |
Alternative Name | MAP3K2, MEKK2B |
Species | Human |
Source | Insect cells |
Description | MEKK2 (also known as mitogen-activated protein kinase (MAPK) kinase kinase 2) is a major upstream activator of the JNK/MAPK cascade . MEKK2 can mediate in vitro phosphorylation of MKK4 and MKK7 which are key MAPKs that activate JNK. In addition, MEKK2 immunoprecipitates activated JUN in an IL1-dependent manner. Rheumatoid arthritis and osteoarthritis synovial tissues show high levels of MEKK2 indicating that it may be an important activator of the JNK pathway in arthritis . Endogenous MEKK2 is localized mainly in the cytosol of unstimulated cells. |
Accession | NM_006609 |
Functions | The specific activity of MEKK2 was determined to be226 nmol /min/mg as per activity assay protocol |
Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 115 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |