| Gene ID | 6364 |
| Accession | P78556 |
| Alternative Name | Beta-chemokine exodus-1, CC chemokine LARC, Liver and activation-regulated chemokine, MIP-3-alpha, Small-inducible cytokine A20, SCYA20, MIP3<br/>Recombinant Human Macrophage Inflammatory Protein-3 Alpha (CCL20) |
| Species | Human |
| Source | E. coli |
| Description | Macrophage inflammatory protein (MIP)-3/CCL20, also known as liver and activation-regulated chemokine (LARC) or Exodus, is a member of the CC chemokine subfamily initially noted to be expressed in human liver, lung, appendix, and tonsillar crypts. MIP-3 is selectively chemotactic for CD34(+) bone marrow cell-derived immature DCs and CD45RO(+) memory T cells that express the cognate receptor CCR6. MIP-3 produced at sites of inflammation may chemoattract CCR6-expressing immature DCs to the subepithelial region of mucosal surfaces. |
| Accession | P78556 |
| Functions | Determined by its ability to chemoattract human monocytes using a concentration range of 2-40 ng/mL. |
| Formulation | Recombinant CCL20 was lyophilized from a 0.2 ?m filtered 20 mM PB,100 mM NaCl solution pH 7.5. |
| Solubility | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Appearance | Lyophilized Powder |
| Molecular Weight | 8 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |