| Gene ID | N/A |
| Accession | BC063044 |
| Alternative Name | NRK2, STK2 |
| Species | Human |
| Source | Insect cells |
| Description | NEK4 or Never In Mitosis A-related kinase 4 is a serine/threonine protein kinase. Northern blot show NEK4 is expressed as 2 mRNAs of 4.0 kb and 6.8 kb in heart and several other tissues. NEK4 gene encodes an 841-amino acid polypeptide and the levels of NEK4 mRNA remain invariant throughout the cell cycle . Nek4 has been identified in a genetic screen as a mediator of response to Taxol . After Taxol treatment, NEK4 promoted microtubule outgrowth, whereas NEK4 deficiency impaired G-M arrest and decreased formation of mitotic-like asters. In contrast, NEK4 deficiency sensitized cells to vincristine, which destabilizes microtubules. |
| Accession | BC063044 |
| Functions | The specific activity of NEK4 was determined to be 15 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 160 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |