| Gene ID |
145957 |
| Accession | Q8WWG1 |
| Alternative Name | Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, NRG4 <br/>Recombinant Human Neuregulin-4 (NRG4) |
| Species | Human |
| Source | E. coli |
| Description | Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells. |
| Accession | Q8WWG1 |
| Functions | The ED(50) was determined by the phosphorylation of ErbB2 and ErbB4 receptors in CHO cells, and was found to be < 3.0 ng/mL, corresponding to a specific activity of 3.0 x 10^5 Units/mg. |
| Formulation | Recombinant Neuregulin-4 was lyophilized from a 0.2 ?m filtered 20 mM PB, pH 6.0. |
| Solubility | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Appearance | Lyophilized Powder |
| Molecular Weight | 7 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
