| Gene ID | N/A |
| Accession | NM_006218, BC021622 |
| Alternative Name | p110a: PI3K, p110-alpha p55g: PIK3R3, p55, p55-GAMMA, FLJ41892 |
| Species | Human |
| Source | Insect cells |
| Description | PI3K (p110alpha/p55gamma) or Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which serve as second messengers in growth signaling pathways. PI3K comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in the PI3K has been associated with insulin resistance and plays an important role in glucose homeostasis in vivo . PI3K also plays an essential role in the development and induction of mast cells in normal and pathogenic immune responses . |
| Accession | NM_006218, BC021622 |
| Functions | The specific activity of PI3K(p110a/p55?)wasdetermined to be 14 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 111 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |