| Gene ID | N/A |
| Accession | NM_006218, NM_181523 |
| Alternative Name | p110α: PIK3CA, MGC142161, MGC142163, p110-alpha p85α: PIK3R1, GRB1, p85-ALPHA |
| Species | Human |
| Source | Insect cells |
| Description | The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110a catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants . PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110a is essential for vascular development and inactivation of p110a leads to severe defects in angiogenic sprouting and vascular remodeling . |
| Accession | NM_006218, NM_181523 |
| Functions | The specific activity of PI3K (p110a/p85a) was determined to be 52 nmol/min/mg as per activity assay protocol. |
| Formulation | 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 111 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |