| Gene ID | N/A |
| Accession | NM_006219, NM_181523 |
| Alternative Name | p110α: PIK3CB, PI3K, PIK3C1, PI3Kbeta, MGC133043, p110-BETA, DKFZp779K1237 p85α: PIK3R1, GRB1, p85-ALPHA |
| Species | Human |
| Source | Insect cells |
| Description | The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110? catalytic subunit (PIK3CB) plays a role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation . In animal model of prostate tumor formation induced by the tumor suppressor PTEN loss, ablation of p110? impedes tumorigenesis with a concomitant diminution of AKT phosphorylation . |
| Accession | NM_006219, NM_181523 |
| Functions | The specific activity of PI3K (p110?/p85a) was determined to be 15 nmol/min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 111 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |