Gene ID | N/A |
Accession | NM_005026, NM_181523 |
Alternative Name | p110δ: p110δp85α: PIK3R1, GRB1, p85-ALPHA |
Species | Human |
Source | Insect cells |
Description | PI3K (p110d/p85a) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring . PI3K (p110d/p85a) plays a role in oncogenic transformation, and is consistently expressed at a high level in blast cells from AML. PI3K (p110d/p85a) can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that lead to neutrophil polarization, and regulates directional migration, but not random locomotion . PI3K (p110d/p85a) signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.? |
Accession | NM_005026, NM_181523 |
Functions | The specific activity of PI3K (p110d/p85a) was determined to be 50 nmol/min/mg as per activity assay protocol. |
Formulation | 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Solubility | N/A |
Appearance | Liquid |
Molecular Weight | 111 |
Purity | 70% - 90% |
Shipping Condition | Dry Ice |
Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |