| Gene ID | N/A |
| Accession | NM_002740 |
| Alternative Name | PRKCI; DXS1179E; MGC26534; nPKC-iota |
| Species | Human |
| Source | Insect cells |
| Description | PKC? is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKC? showed greatest homology to PKCzeta, with 72% identity overall rising to 84% in the catalytic domain. Protein kinase C iota (PKC?) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKC? in the colon are highly susceptible to carcinogen-induced colon carcinogenesis .? |
| Accession | NM_002740 |
| Functions | The specific activity of PKC?was determined to be 664 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 98 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |