| Gene ID | N/A |
| Accession | BC128510 |
| Alternative Name | QSK; SIK-3; L19; FLJ12240; KIAA0999 |
| Species | Human |
| Source | Insect cells |
| Description | ?SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm . Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer . There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA). |
| Accession | BC128510 |
| Functions | The specific activity of SIK3 was determined to be 140 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 62 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |