| Gene ID | N/A |
| Accession | NM_003188, NM_006116 |
| Alternative Name | TAK1: MAP3K7, TGF1a; TAB1: MAP3K7IP1, 3'-Tab1, MGC57664 |
| Species | Human |
| Source | Insect cells |
| Description | TAK1 is a serine/threonine protein kinase that mediates signaling by TGF? and morphogenetic protein (BMP) . In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (Nf?B). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 . Thymocytes lacking TAK1 fail to activate Nf?B and JNK and are prone to apoptosis upon stimulation. |
| Accession | NM_003188, NM_006116 |
| Functions | The specific activity of TAK1-TAB1 was determined to be 10 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 74 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |