| Gene ID | 7043 |
| Accession | P10600 |
| Alternative Name | Transforming growth factor beta-3 |
| Species | Human |
| Source | E. coli |
| Description | Transforming Growth Factor Beta-3 is a disulfide-linked homodimeric, non-glycosylated, protein that is one of the isoforms of the highly pleiotropic cytokines that are secreted by all cell types. TGF Beta-1, TGF Beta-2, and TGF Beta-3 use the same receptor and act as cellular switches that regulate cell growth, proliferation, differentiation, motility, extracellular matrix synthesis, and immune function regulation. Defects of this gene can cause arrhythmogenic right ventricular dysplasia 1 and rienhoff syndrome. TGFB3 first interacts with the accessory receptor betaglycan (TGF Beta-R3) and a type II serine/threonine kinase receptor (TGF Beta-R2). The receptor then activates a type I serine/threonine kinase receptor such as ALK-1 or TGF Beta-R1 (ALK-5) through phosphorylation, and the activated type I receptor activates Smad proteins to regulate transcription. |
| Accession | P10600 |
| Functions | The ED50 is 0.01-0.04 ng/mL as determined by its ability to inhibit IL-4 dependent proliferation of HT-2 mouse cells |
| Formulation | The filter sterilized clear protein solution contains 20% Ethanol and 0.12% Acetic acid. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 13 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Dry Ice |
| Storage Condition | This cytokine can be stored in working aliquots at 2? - 8?C for two weeks. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). |