| Gene ID | 8743 |
| Accession | P50591 |
| Alternative Name | TRAIL, Tumor necrosis factor (Ligand) family member 10, TNFSF10, Apo2 Ligand, TL2<br/>Recombinant Human TNF-Related Apoptosis-Inducing Ligand (TNFSF10) |
| Species | Human |
| Source | E. coli |
| Description | A cytotoxic protein, TRAIL initiates apoptosis in tumor cells by binding the death-signalling receptors; DR4 and DR5. In its active conformation, TRAIL forms homotrimers. TRAIL transcripts have been shown to be constitutively expressed in a variety of human tissues. There are five known TRAIL receptors: two which transduce apoptotic signals, two which function as decoys to block TRAIL-induced apoptosis and osteoptotegrin. |
| Accession | P50591 |
| Functions | N.A. |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS with BSA as a carrier protein. |
| Solubility | Reconstitute at 20 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19.5 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | < 1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |