| Gene ID | N/A |
| Accession | NM_032538 |
| Alternative Name | BDTK; RP3-330M21.4 |
| Species | Human |
| Source | Insect cells |
| Description | ?TTBK1 or tau-tubulin kinase 1 is a recently discovered brain-specific protein kinase involved in tau phosphorylation at Alzheimer?s disease-related sites. Two single nucleotide polymorphisms have been observed in the TTBK1 gene and these may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease . TTBK1 levels are upregulated in brains of human Alzheimer' disease (AD) patients compared with age-matched non-AD controls . Overexpression of TTBK1 in transgenic mice leads to increased phosphorylation-related neurofilament aggregation which results in significant age-dependent memory impairment. |
| Accession | NM_032538 |
| Functions | The specific activity of TTBK1 was determined to be 160 nmol /min/mg as per activity assay protocol. |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 96 |
| Purity | 70% - 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |