| Gene ID | 51330 |
| Accession | Q9NP84 |
| Alternative Name | Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, CD-antigen: CD266 |
| Species | Human |
| Source | E. coli |
| Description | Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is the receptor for TNFSD12/TWEAK and is the smallest member of the TNF receptor superfamily. It is composed of a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic ?death? domain, which can activate a cell?s apoptotic mechanisms. It also promotes endothelial cell proliferation and angiogenesis, and modulates cellular adhesion to matrix proteins. TNFRSF12A expression can be found in the spleen, thymus, small intestine, and colon, and can be activated by membrane-anchored or soluble versions of TWEAK. |
| Accession | Q9NP84 |
| Functions | The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL. |
| Formulation | Lyophilized from a 0.2 ?m filtered solution in PBS |
| Solubility | N/A |
| Appearance | Lyophilized Powder |
| Molecular Weight | 5.6 |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | <1.0 EU/μg of recombinant protein as determined by the LAL method |
| Shipping Condition | Ambient Temperature |
| Storage Condition | The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? - 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |